Endothelial cell anergy, which has been defined by a lack of tumor-related suppression of the expression of E-selectin, ICAM1, and VCAM1 adhesion molecules, was efficiently overcome in HUVEC-T cell cocultures in the presence of EC-targeting bsAb and could be largely attributed to TNF-α secreted by activated T cells. This evidence concerns the gene TNF and neoplasm.