ICAM1 and neoplasm: With the objective of overcoming EC anergy [3,5,83], we reasoned to activate T cells in close proximity to HUVEC by means of bispecific antibodies in order to elicit local secretion of proinflammatory cytokines, that in turn would stimulate HUVEC displaying a phenotype of quiescent tumor endothelial cells with only low levels of ICAM1 expression.