LGALS1 was drastically upregulated in human gastric cancer, and has an important role in iCCA progression by increasing the expression levels of C-C chemokine receptor type 2 (CCR2), ADAM15, a metalloproteinase involved in cell adhesion to ECM, and β-integrin, a transmembrane receptor that plays a crucial role in cell adhesion and migration [49]. Here, CCR2 is linked to gastric cancer.