The high muscle/high adiposity body composition type also exhibited the downregulation of CRAF, ERK2, beta-catenin, Tuberin (TSC2), S6, and AKT proteins, which collectively suggest that the high adiposity in endometrial cancer is associated with alterations in the MAPK and PI3K/AKT/MTOR pathways, both of therapeutic potential in endometrial cancer [51,52]. This evidence concerns the gene AKT1 and endometrial cancer.