The class III obesity (vs. normal/overweight) group was significantly associated with higher expression of CHK1 (log2-fold change = 1.4, p-value = 0.031) and Beclin 1 (log2-fold change = 0.6, p-value = 0.047) but lower expression of androgen receptor (AR; log2-fold-change = −0.8, p-value = 0.039) (Supplemental File S1; Supplemental Figure S4B). The gene discussed is CHEK1; the disease is obesity due to melanocortin 4 receptor deficiency.