A possible explanation for these findings could lie in the fact that the VEGF/VEGFR-signaling axis, encompassing factors like VEGF-A, PlGF, VEGF-B, VEGF-C, and VEGF-D, along with receptors VEGFR-1, VEGFR-2, and VEGFR-3, plays a vital role in melanoma by driving angiogenesis. The gene discussed is VEGFA; the disease is melanoma.