LAG-3 expression was observed in cHL MEs of a subset of pediatric patients, with conflicting results regarding its prognostic role: Jimenez et al. reported an inferior EFS when both PD-1 and LAG-3 molecules were present [24], while in the study of Moerdler et al., patients with the lowest expression density had the worst EFS, and those with the highest showed the best EFS [26]. Here, LAG3 is linked to classic Hodgkin lymphoma.