In the present study, we investigated the ICPI therapeutic targets CTLA-4, LAG-3, PD-1, and PDL1 and the biological markers FOXP3 and CD8, which are respectively representative of specific T-regulatory and cytotoxic T-cell subsets in the subgroup of adolescent cHL patients, and we challenged their prognostic power. This evidence concerns the gene LAG3 and classic Hodgkin lymphoma.