In the present study, we investigated the ICPI therapeutic targets CTLA-4, LAG-3, PD-1, and PDL1 and the biological markers FOXP3 and CD8, representative of specific T-regs and cytotoxic T-cells in a cohort of 36 adolescent cHL patients, challenging their prognostic power. This evidence concerns the gene CD8A and classic Hodgkin lymphoma.