Alonso-Álvarez et al. showed that high CD4+ and low CD8+ T-cells infiltrates in tumor specimens were associate with poor prognosis in cHL adult patients [23], and, recently, Michot et al. found immune CD8+ depletion and overexpression of LAG-3 on CD4+ helper T-cells as possible mechanisms of resistance to immunotherapies in patients with cHL [37]. This evidence concerns the gene LAG3 and neoplasm.