STAT3 and laryngotracheoesophageal cleft: Importantly, previous studies reported that miR126-5p can regulate the proliferation and growth of LC cells by regulating STAT3 activation, [15] while overexpression of miR126-5p in LC cells enhanced growth, migration, and invasion by targeting multiple signaling pathways including the PI3K/AKT/mTOR pathway, VCAM-1, and CCR-1 [15,16,17,18].