In particular, Fang and colleagues, comparing 47 APL, 26 NPM1-mutated AML, and 12 KMT2A-rearranged AML with an APL-like immunophenotype, found that the latter mimics hypogranular APL blasts (low side scatter) showing, though, lower expression of CD2 and CD34; furthermore, NPM1-mutated cases presented lower expression of CD13 and CD64, and KMT2A-rearranged cases lower expression of MPO [158,159]. The gene discussed is CD2; the disease is acute promyelocytic leukemia.