Remarkably, using whole exome sequencing or mutational profiling of a comprehensive 409 tumor suppressors and oncogenes panel, we found a high incidence of ARID1A mutations (five cases, 71%) and mutations in ARID2 and SMARCA4, other tumor suppressor genes belonging to the SWI/SNF chromatin remodeling complex (one case each, 14%) in PLZF-RARA AML [105]. This evidence concerns the gene ZBTB16 and acute myeloid leukemia.