In 2022, Chen et al. [44], through a retrospective transcriptome analysis of patients with AML, identified the third case of TTMV::RARA in a 3-year-old child with hyperleukocytosis and bone marrow (BM) smears infiltrated by 73.6% of hyper-granular promyelocytes. Here, RARA is linked to acute myeloid leukemia.