For example, the C-terminal tail of Cx43 (Cx43-CT) can interact with various oncogenes and may serve as a trigger for intracellular signaling cascades, control metabolic pathways, impact transcriptional control, and potentially be released within extracellular vesicles featuring paracrine cell–cell communication in the tumor microenvironment through its hemichannel function [11,59,60,61]. The gene discussed is GJA1; the disease is neoplasm.