For instance, IL6 induces downregulation of RFX1 and leads to increased production and differentiation of Th-17 cells by decreasing DNA methylation and histone 3 lysine 9 (H3K9) trimethylation and increasing histone acetylation in patients with autoimmune disease SLE (systemic lupus erythematosus) and mice study model [188]. Here, IL6 is linked to autoimmune disease.