IL6 and cancer: In cancer cells, IL6 via JAK/STAT, NFκB, Phosphoinositide-3 Kinase/Protein Kinase B (PI3K/AKT), and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase (MAPK/ERK) pathways upregulates anti-apoptotic proteins such as B Cell Leukemia/Lymphoma-2 protein (BCL2) and Survivin, thus inhibiting proapoptotic activation [61,62,63].