The P2RY8 gene is known to be highly mutated in both hematologic malignancies, diffuse large B-cell lymphoma, and Burkitt lymphoma, driving their pathogenesis [66], and recent evidence also implicated its expression in the development of colorectal carcinoma through promoting the proliferation and migration of cancer cells [67]. The gene discussed is P2RY8; the disease is colorectal carcinoma.