However, diverting from our observations, HCAR1 activation has been reported to augment the proliferation, survival, and metastasis of various cancer cell lines, including colorectal [81], breast [82], ovarian [83], pancreatic [84], hepatocellular [85], and glioblastoma [79], thus marking this MMR as an oncogene. The gene discussed is MRC1; the disease is cancer.