TCGA-CHOL (Cholangiocarcinoma) shows upregulations of HTR3A (35.1-fold) and GPR35 (G Protein-Coupled Receptor 35) (33.9-fold), with downregulations in ADRA1A (−74.3-fold) and ESR1 (Estrogen Receptor 1) (−43.2-fold). The gene discussed is HTR3A; the disease is cholangiocarcinoma.