ESPL1 and neoplasm: Moreover, genes critical for mitotic spindle assembly, chromosome segregation, and cell cycle checkpoint, including KIF14, NUF2, KIF18B, TPX2, ESPL1, CCNE2, and CENPF, are upregulated in the SNMM-enriched cluster B. Alterations in these genes have been associated with a potential compromise in chromosomal segregation accuracy, contributing to the genomic instability characteristic of aggressive tumor types.