KMT2A and acute myeloid leukemia: In this work, we used all the information available for AML samples with known KMT2A-r status, including the karyotype, KMT2A break-apart FISH and transcript analyses, to better characterize the genomic events associated with cryptic or hard-to-characterize KMT2A rearrangements using OGM and to evaluate the limits of this technology for the study of these genetic alterations.