EZH2 and neoplasm: In neuroblastoma, G9a and GLP were found to have a positive correlation with MYCN expression, and increased H3K9me2 and H3K27me3 at the CXCL9, CXCL10, and CXCL11 chemokine cluster indicated the potential role of G9a, GLP, and EZH2 in maintaining a ‘cold’ tumor microenvironment [130].