Haploinsufficiency for PRC2 components has also been linked to increasingly aggressive clinical behavior in pediatric AML [84], while EED or SUZ12 inactivation is recurrently observed in sporadic, Neurofibromatosis type 1 (NF1)-associated, and radiotherapy-associated Malignant Peripheral Nerve Sheath Tumor (MPNST) [85]. This evidence concerns the gene NF1 and malignant peripheral nerve sheath tumor.