SETDB1 and diffuse astrocytoma: SUV39H1 expression was found to be increased in pilocytic astrocytomas, while SETDB1 expression has been found to be upregulated in pediatric high-grade gliomas (pHGGs), including diffuse astrocytomas and glioblastomas, indicating that SUV39H1 may establish H3K9me3 in grade I tumors, while SETDB1 may establish the same mark in high-grade tumors [127,128].