Another key factor in PCa progression and metastasis is the epithelial–mesenchymal transition (EMT), characterized by the decreased expression of epithelial cell markers, such as E-cadherin and occludins, and the increased expression of mesenchymal markers, such as vimentin and N-cadherin [41,42,43,44,45,46]. The gene discussed is CDH2; the disease is posterior cortical atrophy.