Muscle mass loss in whole-body BNIP3 knockout mice upon colorectal MC38 or pancreatic ductal Pan02 carcinoma was prevented, supporting the potential of targeting BNIP3 for fighting cancer cachexia, although the chronic and ubiquitous BNIP3 deficit does not allow for the dissection of the specific contribution of muscle mitophagy to the resulting phenotype [38]. Here, BNIP3 is linked to cancer.