BNIP3 and neoplasm: It is worth mentioning that using the same silencing strategy, i.e., the same plasmid backbone, electroporation protocol and tumor model, although targeting different genes such as muscle-specific ubiquitin ligases, was effective in counteracting muscle fiber atrophy [39], supporting the idea that the experimental system is potentially adequate; however, the induction of BNIP3 overcame the current silencing capacity.