This approach not only stimulated T helper 1 (Th1) immune responses and regulated the tumor’s immune environment, but also enhanced Th1-associated gene expression and T-cell infiltration, notably CD8+ T cells driven by C-X-C motif chemokine ligand 10, without markedly affecting the Th2, Th17, or Treg genes [104]. Here, CD8A is linked to neoplasm.