The tumor microenvironment (TME) further complicates immune engagement, characterized by immunosuppressive elements such as regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs), and cytokines like transforming growth factor-beta (TGF-β) and interleukin-10 (IL-10), which inhibit the function of key immune cells including cytotoxic T lymphocytes and natural killer cells [94,95,96]. The gene discussed is IL10; the disease is neoplasm.