SCGN and diabetes mellitus: All significant correlations of ERS biomarkers with BMI, HbA1c, glucose, HOMA-B, and HOMA-IR point toward the clinical relevance of HSP70, GRP78, PRX1, PRX2, PRX4, PRX6, and SCGN, as they are not only elevated in patients with diabetes but also correlate with glucometabolic variables (Figure 5).