Saito et al. [37], in a study conducted on mice with deliberately developed pancreatic cancer as well as on cells line, proved that XN, by inhibiting NF-kB, contributes to the reduced VEGF (Vascular-endothelial growth factor) and IL-8 (Interleukin 8) responsible for angiogenesis on the level of mRNA and pancreatic cancer cells. Here, NFKB1 is linked to familial pancreatic carcinoma.