By downregulating the hypoxia-inducible factor 1-alpha/vascular endothelial growth factor/vascular endothelial growth factor receptor 2 (HIF-1α/VEGF/VEGFR2) signaling pathway, flavonoids effectively reduce the expression of critical mediators of choroidal neovascularization (CNV) [28,36]. The gene discussed is VEGFA; the disease is choroidal neovascularization.