Similarly, qPCR analysis showed that RNA expression of psoriasis-related cytokines (Tnfα and Il1β) and psoriasis-related antibacterial peptides (Defb4, S100a7, S100a8, and S100a9) in IL-17-stimulated HaCaT cells was significantly suppressed by limonin in the siControl group, but this suppression was not observed in the siAMPK group (Figure 6e). This evidence concerns the gene S100A7 and psoriasis.