TNF and psoriasis: Furthermore, quantitative analysis of the expression of inflammatory cytokines and psoriasis-related mediators showed that limonin significantly inhibited the expression of inflammatory cytokines, such as Tnfα and Il1β (Figure 1g) and psoriasis-related mediators, such as Defb4, S100a7, S100a8, and S100a9 compared with those in the TPA-induced group (Figure 1h).