Moreover, extramitochondrial oxidation mediated by enzymes like nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, xanthine oxidase, cyclooxygenases, lipoxygenases, and inducible nitric oxide synthase (iNOS) [47] also contributes to the elevated ROS/RNS production in MASLD [48]. The gene discussed is NOS2; the disease is metabolic dysfunction-associated steatotic liver disease.