However, in a significant study in a group of patients with LN, levels of Nrf2 in serum, in glomeruli, and mesangium were positively correlated with the estimated glomerular filtration rate (the protective effect in the kidney) and were also inversely correlated with SLEDAI, indicating diffuse protection for other inflammatory sites [32]. The gene discussed is NFE2L2; the disease is lobular neoplasia.