SOD1 and lobular neoplasia: Given the association of anti-SOD antibodies with proteinuria and in consideration of the studies indicating up-regulation of the expression of SOD by podocytes in vitro and in vivo, the same multi-step mechanism was proposed for LN which was proposed above for MN, in which the first antibody (anti-dsDNA, anti-ENO in the case of LN) induces oxidative stress followed by up-regulation of SOD and anti-SOD antibodies.