AIP and familial isolated pituitary adenoma: Table 1 summarizes the mitochondrial gene mutations identified in pituitary adenomas and the associated disease types. Beyond mutations in genes belonging to the mitochondrial proteome, the genetic landscape of pituitary adenomas has been thoroughly investigated. For example, Daly et al. found that approximately 15% of families with FIPA harbor germline mutations in the AIP gene [29], which are linked to larger adenomas and younger patient presentations.