Activation of Nrf2 with sulforaphane or omaveloxolone (RTA-408) was shown to reverse bioenergetic deficits in cultured neurons within a PINK1-deficient PD model and prevent neuronal death, confirming the role of Nrf2 activation in supporting mitochondrial bioenergetics in neurons [43]. The gene discussed is NFE2L2; the disease is Parkinson disease.