ATXN3 and neuroblastoma: To further explore the therapeutic potential of HEME in SCA3, we used human neuroblastoma SK-N-SH-MJD78 cells and ELAV-SCA3tr-Q78 Drosophila expressing full-length ataxin-3 with 78 CAG repeats and an ataxin-3 polyQ tract of 78 residues, respectively, to assess the beneficial impacts and possible molecular mechanisms of HEME against mutant ataxin-3-induced neuronal damage.