GPI and cancer: Additionally, it has also been seen that they are rich in enzymes involved in cancer-related metabolic processes, such as glyceraldehyde-3-phosphate dehydrogenase (GAPDH), lactate dehydrogenase B (LDHB), heat shock 70-kDa protein 5 (HSPA5), malate dehydrogenase (MsDH), and glucose-6-phosphate isomerase (GPI).