GLP1R and type 2 diabetes mellitus: Over the past few decades, a range of antihyperglycemic agents have been utilized in the treatment of T2D, including metformin; sulfonylureas, such as glipizide; alpha-glucosidase inhibitors, such as acarbose; and glucagon-like peptide-1 receptor (GLP-1R) agonists [7,8].