Compared to the MC group, intervention with blueberry polyphenols resulted in varying degrees of decreased expression of the cell death-inducing DNA fragmentation factor-alpha-like effector a (Cidea), Cidec, Perilipin 4 (Plin4), Perilipin 5 (Plin5), lipin 1 (Lpin1) and lipin (Lpin2) genes in the livers of mice, indicating an improvement in hepatic lipid droplet formation and metabolic homeostasis in T2D mice. This evidence concerns the gene PLIN4 and type 2 diabetes mellitus.