These results indicated that the supernatant from LN-CXCL5 cells induced expression of HO-1, which reduced the levels of ROS induced by H2O2 in WPMY-1 cells, while SB225002 inhibited these effects, suggesting that CXCL5 secretion from prostate cancer cells enhanced the antioxidation of WPMY-1 cells (Figure 7B). This evidence concerns the gene HMOX1 and Familial prostate cancer.