The PPI network showed that the key proteins involved were PPARG, MTOR, IL-6, ESR1, EGFR, STAT3, SRC, and PTGS2, which might be attributed to the regulation of the key compounds hispidin, inoscavin A, inoscavin C, and phellibaumin B. Moreover, the core targets affected by HNMS3 treatment mainly involved mental health and neurodegenerative diseases. This evidence concerns the gene ESR1 and neurodegenerative disease.