Likewise, the use of ethanolic extracts of Sanguisorba officinalis L. in keratinocytes reduced the expression of IL-8 at both the protein and mRNA levels [36], or pomegranate extracts enriched in ellagitannins that were able to inhibit the production of free radicals in the skin and decrease the expression of COX-2, protecting it from DNA damage and thus reducing the risk of skin cancer [37]. The gene discussed is CXCL8; the disease is skin cancer.