Additionally, when assessing fibrin susceptibility to plasmin-induced lysis, evaluated by quantifying the degradation of the fibrin β chain over 0 to 6 h of plasmin digestion (Figure 5A), fibrin from EM patients showed significantly higher levels of undigested fibrin compared to controls (74 [55–85] vs. 23 [20–29]; p < 0.0001), indicating increased resistance to fibrinolysis in EM patients (Figure 5B). This evidence concerns the gene PLG and erythema multiforme.