Genetic polymorphisms in MnSOD, such as Ala16Val, substitution at position 16 of the MnSOD protein, and changing an alanine (Ala) to a valine (Val), are associated with obesity, where the Val variant disrupts mitochondrial targeting and links MnSOD dysfunction with increased obesity risk [8]. This evidence concerns the gene SOD2 and obesity due to melanocortin 4 receptor deficiency.