Notably, a study by Sliter et al. shows that the combination of mtDNA mutational stress with the absence of mitophagy-related proteins leads to dopaminergic neurodegeneration and motor defects that are rescued by genetic inactivation of STING, thus linking mito-inflammation and the cGAS–STING pathway with the onset of PD-like pathology [75]. Here, CGAS is linked to Parkinson disease.