NLRP3 and Mental deterioration: The involvement of the NLRP3 inflammasome in promoting chronic brain inflammation and neurodegeneration is further supported by preclinical studies, which show that NLRP3 ablation in APPswe/PSEN1dE1 mice induces a microglial shift toward an anti-inflammatory phenotype, associated with lower Aβ deposition and improvement in cognitive decline [54].