EIF2A and neuroblastoma: Exposure of SH-SY5Y human neuroblastoma cells to ACR showed an increase in levels of phosphorylated eukaryotic translation initiation factor 2α (eIF2α), and activation of transcription factor 4 (ATF4) [16], and chronic exposure of male mice to ACR has been shown to cause elevated DNA damage in the germline and heritable induction of CYP2E1 in the testes [17].