IFNGR1 and neoplasm: The Interferon-Gamma Receptor 1 (IFNGR1) gene affects the development and metastasis of solid cancers [21,22] as demonstrated in murine mammary carcinoma 4T1 after being implanted into the mammary fat pads of IFN-gamma(−/−) mice, where the tumor developed and metastasized considerably rapidly [23].