Resibufogenin can induce apoptosis in many kinds of tumour cells: Resibufogenin can act on human hepatocellular carcinoma cells Bel-7402, resulting in the increase of Bax protein expression, which has a promotion effect on the generation of apoptosis and has a synergistic effect on the decrease of Bcl-2 protein expression, and can also cause the decrease of mitochondrial transmembrane potential, the increased release of cytochrome C, the activation of caspase-3, and the inhibition of the expression of Bcl-2 protein, inducing cell apoptosis. This evidence concerns the gene BCL2 and neoplasm.