Resibufogenin can regulate the PI3K/Akt/CREB pathway, increase the expression of caspase-3 protein, reduce the level of proto-oncogene PIM1 to inhibit the process of glycolysis, and induce apoptosis of ovarian cancer cells; Resibufogenin can regulate the PI3K/Akt/CREB pathway, increase the expression of caspase-8 protein, regulate PI3K/Akt/Akt/CREB pathway, and inhibit the process of glycolysis. Here, CREB1 is linked to ovarian cancer.