EGFR and neoplasm: Protein kinase is one of the important targets on multiple signalling pathways such as EGFR tyrosine kinase inhibitor resistance signalling pathway, MAPK signalling pathway, ErbB signalling pathway, Ras signalling pathway, Rap1 signalling pathway, and so on, which are related to tumour cell proliferation, differentiation, tumour development, as well as immunotherapy in the process of anti-tumour [33,34,35,36].