Compared with the HFD group, the HFD + CF group showed a significant increase in the autophagy regulatory factor gene Atg7, the autophagosome membrane protein gene Lc3, the pexophagy-specific receptor protein genes Nbr1 and P62, and the peroxisome membrane protein genes Pex2 and Pex14. The gene discussed is SQSTM1; the disease is cystic fibrosis.