SREBF2 and steatosis: For instance, the forced oral administration of medium-chain fatty acids to mice fed a 45% HFD for 12 weeks prevented increases in plasma TG, T-CHO, and LDL-C levels and improved steatosis by inhibiting the induction of fatty liver-related proteins SREBP2, SREBP1c, FAS, and ACC in the liver of obese mice [46].