The analysis of mitophagy protein expression showed that PINK expression levels were only affected by MD in the long term in the HCF, while Parkin expression levels were influenced by MD in a sex- and region-dependent manner in the short term: MD induced a decrease in Parkin expression levels among female animals in the two brain regions analysed, whereas, among males, MD increased Parkin expression levels exclusively in the HFC. Here, PRKN is linked to Menkes disease.