SIRT1 and cancer: ISL exhibits diverse pharmacological properties in animal models, demonstrating anti-cancer, cardioprotective, hepatic, neuroprotective, and renal-protective effects, largely attributed to its antioxidant and anti-inflammatory capabilities through the modulation of pathways such as sirtuin-1 (SIRT1), nuclear factor erythroid factor-2 (Nrf2), and NF-κB [35,36,37].