The common signaling pathways targeted include PI3K-Akt and AMPK in the low-fat diet; PI3K-Akt, NF-kappa B, HIF-1, and insulin resistance in MD + EVOO and FoxO; and PI3K-Akt, AMPK, p53, and HIF-1 in MD + Nuts. This evidence concerns the gene AKT1 and Insulin resistance.