Furthermore, a recent study on gestational diabetes mellitus (GDM) provided evidence of exo-lncRNA–protein interactions, demonstrating that lncRNA GAS5 can dock with HECT and RLD domain-containing E3 ubiquitin protein ligase 5 (HERC5), a critical regulator of immune response [78,79], suggesting lncRNA–protein interactions. This evidence concerns the gene GAS5 and gestational diabetes.