Although the composition of the TME is influenced by the tumor type, several elements are consistently found in the stroma, such as immune cells (monocytes, macrophages, dendritic cells, lymphocytes, and neutrophils); stromal cells (fibroblasts and endothelial cells); extracellular matrix components (glycoproteins, collagen, and enzymes); cytokines (IL-6, IL-17, and IL-23); and blood vessels [9]. This evidence concerns the gene IL6 and neoplasm.