IL6 and neoplasm: CAFs also indirectly stimulate metastasis through their interactions with TAMs: several CAFs-released cytokines recruit TAMs, such as CCL2 and CCL5 (chemokine ligand 2/5), while IL-4 and IL-6 polarize TAMs toward the M2 phenotype, which supports tumor growth and metastasis [80,81,82,83].