The mRNA expression level of all twelve hub genes (CCNB1, AURKA, RACGAP1, CEP55, SMC4, RRM2, PRC1, CKAP2, SMC2, UHRF1, FANCI, and SMC3) in primary liver cancer tissues was highly up-regulated compared to normal tissues (Figure 4). The gene discussed is CCNB1; the disease is liver cancer.