Therefore, given these considerations, this study suggests that these eleven hub genes (CCNB1, AURKA, RACGAP1, CEP55, SMC4, RRM2, PRC1, CKAP2, SMC2, UHRF1, and FANCI) can be potential prognostic biomarkers and therapeutic targets in HCC. The gene discussed is SMC4; the disease is hepatocellular carcinoma.