Therefore, given these considerations, this study suggests that these eleven hub genes (CCNB1, AURKA, RACGAP1, CEP55, SMC4, RRM2, PRC1, CKAP2, SMC2, UHRF1, and FANCI) can be potential prognostic biomarkers and therapeutic targets in HCC. Here, PRC1 is linked to hepatocellular carcinoma.