Therefore, given these considerations, this study suggests that these eleven hub genes (CCNB1, AURKA, RACGAP1, CEP55, SMC4, RRM2, PRC1, CKAP2, SMC2, UHRF1, and FANCI) can be potential prognostic biomarkers and therapeutic targets in HCC. This evidence concerns the gene SMC2 and hepatocellular carcinoma.