The increased levels of FXRα and β-Klotho in curcumin-supplemented groups may be attributed to the improved gut microbiota, as Parabacteroides—which increased following curcumin supplementation—has been shown to alleviate obesity-related dysfunctions and activate intestinal gluconeogenesis and FXR signaling by generating succinate and secondary bile acids. This evidence concerns the gene NR1H4 and obesity due to melanocortin 4 receptor deficiency.