In humans, HCN1 has been proved to be involved in epilepsy diseases, including genetic generalized epilepsies, epilepsy with febrile seizures plus, epileptic encephalopathy, early infantile epileptic encephalopathy, catastrophic epilepsies, and so on [33]. This evidence concerns the gene HCN1 and Febrile seizure (within the age range of 3 months to 6 years).