As shown in Figure 7, high expression of RRM2, MELK, KIF23, NCAPG, BUB1B, AURKB, CCNB1, KIF20A, CCNA2, TTK, PBK, TOP2A, CDK1, MAD2L1, BIRC5, ASPM, CDCA8, CENPF, KIF11, and DLGAP5 indicated significantly unfavorable overall survival in patients with HCC. The gene discussed is CDCA8; the disease is hepatocellular carcinoma.