As shown in Figure 7, high expression of RRM2, MELK, KIF23, NCAPG, BUB1B, AURKB, CCNB1, KIF20A, CCNA2, TTK, PBK, TOP2A, CDK1, MAD2L1, BIRC5, ASPM, CDCA8, CENPF, KIF11, and DLGAP5 indicated significantly unfavorable overall survival in patients with HCC. This evidence concerns the gene PBK and hepatocellular carcinoma.