Eleven hub genes AURKA, BUB1B, TOP2A, MAD2L1, CCNA2, CCNB1, BUB1, KIF11, CDK1, CCNB2, and TPX2 were obtained as hub genes by analyze expression profiles GSE101685, GSE62232, GSE46408, and GSE45627 between HCC and normal hepatic tissues [62]. This evidence concerns the gene BUB1B and hepatocellular carcinoma.