Transcriptome analysis in HCC revealed upregulated ASPM, AURKA, CCNB2, CDC20, PRC1, and TOP2A and downregulated AOX1, CAT, CYP2E1, CYP3A4, and HP as key prognostic genes by GSE36376, GSE39791, GSE57957, and GSE87630 analysis [60]. The gene discussed is TOP2A; the disease is hepatocellular carcinoma.