The expression of hub genes RRM2, MELK, KIF11, KIF23, NCAPG, DLGAP5, BUB1B, AURKB, CCNB1, KIF20A, CCNA2, TTK, PBK, TOP2A, CDK1, MAD2L1, BIRC5, ASPM, CDCA8, and CENPF was validated using GEPIA in HCC. This evidence concerns the gene BIRC5 and hepatocellular carcinoma.