The results of the mentioned studies by analysis of the microarray GSEs related to HCC with different bioinformatics methods revealed CDC20, TOP2A, ASPM, BUB1B, MAD2L1, KIF20A, AURKA, CCNA2, CCNB1, KIF11, CDK1, and CCNB1 as hub genes in HCC, which is consistent with our study and confirms the importance of these genes in HCC. The gene discussed is MAD2L1; the disease is hepatocellular carcinoma.