Transcriptome analysis in HCC revealed upregulated ASPM, AURKA, CCNB2, CDC20, PRC1, and TOP2A and downregulated AOX1, CAT, CYP2E1, CYP3A4, and HP as key prognostic genes by GSE36376, GSE39791, GSE57957, and GSE87630 analysis [60]. This evidence concerns the gene ASPM and hepatocellular carcinoma.