Gene pathway analysis of the identified hub genes included RRM2, MELK, KIF11, KIF23, NCAPG, DLGAP5, BUB1B, AURKB, CCNB1, KIF20A, CCNA2, TTK, PBK, TOP2A, CDK1, MAD2L1, BIRC5, ASPM, CDCA8, and CENPF revealed their performance in HCC‐related pathways. Here, CENPF is linked to hepatocellular carcinoma.