At a CRC risk threshold of 0.6% (equivalent to f‐Hb = 10 μg Hb/g (μg/g)) overall performance of the validated model across age strata using Harrell's C index was ≥ 0.91% (overall C‐statistic 93%, 95% CI 92%–95%) with acceptable calibration. This evidence concerns the gene GSTM1 and colorectal carcinoma.