We revealed that CHDH affects histone H3 trimethylation, which upregulates the expression of P4HA family genes (P4HA1/2/3) to stabilize and promote the expression of collagen I and increases the expression of IL17RB to promote the downstream activation of c‐Jun, which together contribute to CRC metastasis. This evidence concerns the gene CHDH and colorectal carcinoma.