As a key member of the mitogen‐activated protein kinases, activated c‐Jun N‐terminal kinase (JNK) recognizes and binds to the amino‐terminal region of c‐Jun, and bisphosphorylates serine‐63 and serine‐73 sites in the activation region of c‐Jun, which activates and enhances its transcriptional activity, thereby regulating tumor proliferation, apoptosis, and metastasis.31 This evidence concerns the gene MAPK8 and neoplasm.