The NOVA (neuro-oncologic ventral antigen) protein was first identified as an autoantigen in a neurological disease called paraneoplastic opsoclonus-myoclonus ataxia, characterized by motor and cognitive impairments (Buckanovich et al., 1993; Luque et al., 1991), and was the first RNA-binding protein described as a splicing regulator of neuron-specific exons (Jensen et al., 2000). The gene discussed is PTBP1; the disease is nervous system disorder.