On the other hand, mutations or dysfunction of TDP43 and FUS are associated with widespread splicing misregulation, which leads to neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) (Vuong C. K. et al., 2016). Here, TARDBP is linked to amyotrophic lateral sclerosis.