HTT and Huntington disease: It is known that 3-NPA can induce striatal degeneration through its neurotoxic activity in rodents and result in gait abnormalities, which mimicking the behavioral dysfunction and pathology caused by mutant Htt in animal models for HD and its patients (Brouillet et al., 2005; Huang et al., 2006; Tunez et al., 2010).