Alzheimer’s disease manifests as a neurodegenerative condition with hallmark pathologies: the intracellular presence of phosphorylated tau and the extracellular presence of β-amyloid plaques (Nalivaeva et al., 2020; Yiannopoulou and Papageorgiou, 2020). Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.